It is a nonbarbiturate-sedative, which depresses central nervous system function by activating gamma-aminobutyric acid (GABA) receptors. Usually, emergent endotracheal intubation is indicated in the following clinical scenarios :Įtomidate is the most commonly used induction agent for rapid sequence intubation. This article gives an overview of indications, mechanism of action of commonly used sedatives and paralytics, endotracheal tubes, the sequence of steps in rapid sequence intubation, adverse effects of intubations and medications, and important contraindications. Rapid sequence intubation involves the simultaneous rapid administration of a paralytic drug and an induction agent to create optimal conditions to provide rapid control of the airway with the placement of an endotracheal tube. In a rapidly deteriorating, critically ill patient, success rests on adequate preparation, experience, and anticipated difficulty associated with airway, clinical condition, and intubation. Mastering the skill of endotracheal intubation to secure an airway plays a critical role in many settings such as pre-hospital environments, emergency rooms, critical care units, and peri-operative medicine.

This activity describes the mode of action of various agents used in the intubation process, including mechanisms of action, pharmacology, adverse event profiles, eligible patient populations, monitoring, and highlights the role of the interprofessional team in the management of conditions where medications to facilitate emergent intubation offers an advantage. Rapid sequence intubation involves the simultaneous rapid administration of a person with paralysis and an induction agent to create optimal conditions to provide rapid control of the airway with the placement of an endotracheal tube.